Author

A. P. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

B. V. Tsu· 3 shared M. D. Daugherty· 3 shared C. Beierschmitt· 2 shared P. S. Mitchell· 2 shared R. Agarwal· 2 shared A. D. Vegas· 1 shared A. Garfield· 1 shared A. S. Don· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. V. Tsu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

A. D. Vegas, S. Madsen, K. C. Cooke, L. Carroll, J. X. Y. Khor, N. Turner, X. Y. Lim, M. A. Astore, J. Morris, A. S. Don, A. Garfield, S. Zarini, K. A. Zemski Berry, A. P. Ryan, B. C. Bergman, , J. G. Burchfield

The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.

bioRxiv · Mar 10, 2023 · PreprintCell Biology

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL

D. A. Stevens, C. Beierschmitt, S. Mahesula, M. R. Corley, J. Salogiannis, B. V. Tsu, B. Cao, A. P. Ryan, S. L. Reck-Peterson, M. D. Daugherty

This study identifies NINL as an antiviral innate immune component targeted by viruses through proteolytic cleavage, revealing its role in interferon response and viral antagonism.

bioRxiv · Jul 11, 2022Microbiology

Diverse viral proteases activate the NLRP1 inflammasome

B. V. Tsu, C. Beierschmitt, A. P. Ryan, R. Agarwal, P. S. Mitchell, M. D. Daugherty

This study identifies viral proteases from picornaviruses that activate human NLRP1 inflammasome through specific cleavage, revealing a host-specific immune response mechanism.

bioRxiv · Oct 16, 2020Microbiology