V. Oksenych

Tyrosine kinase inhibitors target B cells

The paper tests tyrosine kinase inhibitors on B cells, finding some drugs target LTK-positive plasma cells and inhibit B cell proliferation.

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

Acetyltransferases GCN5 and PCAF are required for B lymphocyte maturation in mice

This study shows that GCN5 and PCAF are essential for B cell maturation and class switch recombination in mice.

Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study

This study examines how active components of commonly prescribed medicines affect influenza A virus-host cell interactions both in silico and in vitro.

Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection by targeting cooperatively host TMPRSS2 in vitro and in vivo

This study combines nafamostat and interferon-alpha to suppress SARS-CoV-2 infection by targeting TMPRSS2 in vitro and in vivo.

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

Identification of novel antiviral drug combinations in vitro and tracking their development

This study identifies novel synergistic antiviral drug combinations effective against SARS-CoV-2, echovirus 1, HCV, and HIV-1 in vitro and provides an online resource for their developmental status.

Potential antiviral options against SARS-CoV-2 infection

The paper identifies potent convalescent sera and broad-spectrum antivirals effective against SARS-CoV-2 using a neutralization assay and cell culture screening.

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

This study shows that XLF is functionally redundant with MRI and PAXX in lymphocyte development, and Mri interacts genetically with Dna-pkcs and Paxx in mice.

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

Critical Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

This study identifies critical host-virus interaction nodes through network analysis and drug re-purposing, revealing key targets for antiviral therapies.