Author

E. Rodrigues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. S. Macauley· 4 shared F. Mozaneh· 2 shared J. C. Paulson· 2 shared J. Jung· 2 shared J. S. Klassen· 2 shared S. Sarkar· 2 shared A. Bhattacherjee· 1 shared A. Khalil· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

M. S. Macauley

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5 papers

Recent·Most cited

A new method for the reproducible development of aptamers (Neomers)

C. Meehan, E. L. Hamilton, C. G. Mansour, S. Lecocq, C. J. Drake, Y. An, E. Rodrigues, G. Penner

This paper introduces a new aptamer selection method called Neomers, which improves reproducibility and specificity by mimicking immune tolerance through structured random nucleotide libraries.

bioRxiv · Dec 19, 2023Biochemistry

Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands

J. Jung, J. R. Enterina, D. T. Bui, F. Mozaneh, P.-H. Lin, H. Nitin, C.-W. Kuo, E. Rodrigues, A. Bhattacherjee, P. Raeisimakiani, G. C. Daskhan, C. D. St. Laurent, K.-H. Khoo, L. K. Mahal, W. F. Zandberg, , M. S. Macauley

This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.

ACS Chemical Biology · Oct 18, 2021Peer-reviewedImmunology

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

E. Rodrigues, J. Jung, H. Park, C. Loo, S. Soukhtehzari, E. N. Kitova, F. Mozaneh, G. Daskhan, V. Aghanya, S. Sarkar, L. Streith, C. St. Laurent, J.-P. Julien, L. C. West, K. C. Williams, , M. S. Macauley

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

bioRxiv · Jul 28, 2020Biochemistry

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

S. Hong, C. Yu, Y. Shi, P. Wang, D. G. Chapla, E. Rodrigues, K. W. Moremen, J. C. Paulson, M. S. Macauley, P. Wu

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

bioRxiv · Jul 15, 2020 · PreprintBiochemistry

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

M. Sojitra, S. Sarkar, J. Maghera, E. Rodrigues, E. J. Carpenter, S. Seth, D. F. Vinals, N. J. Bennett, R. Reddy, A. Khalil, X. Xue, M. Bell, R. B. Zheng, P. Zhang, C. Nycholat, , R. Derda

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

bioRxiv · Mar 24, 2020Biochemistry