Author

K. W. Moremen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Bioengineering· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 6 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 4 Organism:Arabidopsis· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Chapla· 4 shared D. G. Chapla· 4 shared P. Wu· 4 shared S. Hong· 4 shared C. Yu· 3 shared G.-J. Boons· 3 shared J.-Y. Yang· 3 shared B. Urbanowicz· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

D. Chapla

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Exploiting Substrate Specificities of 6-O-Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides

Y. Wu, G. Vos, C. Huang, D. Chapla, A. Kimpel, K. W. Moremen, R. P. de Vries, G.-J. Boons

This paper uses sulfotransferase substrate specificities to enzymatically synthesize keratan sulfate oligosaccharides and investigates their binding properties with lectins and viral proteins.

bioRxiv · Aug 20, 2023Biochemistry

The Plasminogen-Apple-Nematode (PAN) domain suppresses JA/ET defense pathways in plants

K. De, D. Pal, C. M. Shanks, T. B. Yates, K. Feng, S. Jawdy, M. M. Hassan, P. K. Prabhakar, J.-Y. Yang, D. Chapla, K. W. Moremen, B. Urbanowicz, W. Muchero, B. Binder

The study shows the PAN domain in G-type lectin receptor-like kinases suppresses JA/ET defense pathways in plants by promoting receptor degradation.

bioRxiv · Jun 15, 2023 · PreprintPlant Biology

Sequential in vitro enzymatic N-glycoprotein modification reveals site-specific rates of glycoenzyme processing

T. M. Adams, P. Zhao, D. Chapla, K. W. Moremen, L. Wells

The paper investigates site-specific rates of glycan processing in vitro and finds that local structural factors influence enzymatic modification efficiency and microheterogeneity.

bioRxiv · Jul 27, 2022Biochemistry

Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function

M. O. Sheikh, C. J. Capicciotti, L. Liu, J. L. Praissman, D. G. Mead, M. A. Brindley, T. Willer, K. P. Campbell, K. W. Moremen, L. Wells, G.-J. Boons

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

bioRxiv · May 10, 2021Biochemistry

Glycan remodeled erythrocytes facilitate antigenic characterizationof recent A/H3N2 influenza viruses

F. Broszeit, R. J. van Beek, L. Unione, T. M. Bestebroer, D. Chapla, J.-Y. Yang, K. W. Moremen, S. Herfst, R. A. M. Foucher, R. P. de Vries, G.-J. Boons

The paper demonstrates that glycan remodeling of erythrocytes enables antigenic characterization of recent A/H3N2 influenza viruses that lack agglutination ability.

bioRxiv · Dec 18, 2020Biochemistry

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

S. Hong, C. Yu, Y. Shi, P. Wang, D. G. Chapla, E. Rodrigues, K. W. Moremen, J. C. Paulson, M. S. Macauley, P. Wu

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

bioRxiv · Jul 15, 2020 · PreprintBiochemistry

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

S. Hong, C. Yu, P. Wang, Y. Shi, B. Cheng, M. CHEN, D. G. Chapla, N. Reigh, Y. Narimatsu, X. Chen, H. Clausen, K. W. Moremen, M. S. Macauley, J. C. Paulson, P. Wu

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

bioRxiv · Mar 23, 2020Bioengineering

Structure of the Xylan O-Acetyltransferase AtXOAT1 Reveals Molecular Insight into Polysaccharide Acetylation in Plants

B. Urbanowicz, V. Lunin, H.-T. Wang, V. Bharadwaj, P. M. Alahuhta, M. J. Pena, J.-Y. Yang, S. A. Archer-Hartmann, P. Azadi, M. Himmel, K. W. Moremen, W. S. York, Y. J. Bomble

The paper characterizes AtXOAT1, a plant xylan O-acetyltransferase, revealing its structural and mechanistic details for xylan acetylation.

bioRxiv · Jan 16, 2020 · PreprintBiochemistry

hFUT1-based live cell assay to profile α1-2-fucosides enhanced influenza A virus infection

S. Hong, G. Grande, C. Yu, D. G. Chapla, N. Reigh, Y. Yang, K. Izumori, K. W. Moremen, J. Xie, P. Wu

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

bioRxiv · Nov 25, 2019Biochemistry

Direct Visualization of Live Zebrafish Glycan via Single-step Metabolic Labeling with Fluorophore-tagged Nucleotide Sugars

S. Hong, P. Sahai-Hernandez, D. G. Chapla, K. W. Moremen, D. Traver, P. Wu

The paper develops a single-step fluorescent glycan labeling method to image sialylation and fucosylation in live zebrafish embryos, revealing their roles in hematopoiesis.

bioRxiv · Jun 20, 2019Biochemistry