Author

D. Hochhauser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Millman· 2 shared R. Sorek· 2 shared A. Bernheim· 1 shared A. Kacen· 1 shared A. Leavitt· 1 shared A. Lopatina· 1 shared A. Sottoriva· 1 shared A. Stokar-Avihail· 1 shared

Activity by Year

2022-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

A. Millman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

The defence island repertoire of the Escherichia coli pan-genome

D. Hochhauser, A. Millman, R. Sorek

The paper maps defence islands in E. coli genomes, showing they integrate at specific hotspots via mobile genetic elements, explaining strain-specific immune variation.

bioRxiv · Jun 9, 2022Microbiology

An expanding arsenal of immune systems that protect bacteria from phages

A. Millman, S. Melamed, A. Leavitt, S. Doron, A. Bernheim, J. Hör, A. Lopatina, G. Ofir, D. Hochhauser, A. Stokar-Avihail, N. Tal, S. Sharir, M. Voichek, Z. Erez, J. L. M. Ferrer, , R. Sorek

This study identifies 21 new bacterial defense systems against phages through genomic analysis and experiments, revealing novel protein domains and toxin-antitoxin mechanisms involved in anti-phage immunity.

bioRxiv · May 11, 2022Microbiology

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

H. Kayhanian, P. Barmpoutis, E. Lakatos, W. C. H. Cross, G. Caravagna, L. Zapata, K. Litchfield, C. D. Steele, W. Waddingham, D. Patel, S. Milite, C. Jin, A.-M. Baker, C. Ross, D. Alexander, , M. Jansen

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

bioRxiv · Mar 6, 2022 · PreprintCancer Biology