Author

P. Vlckova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. J. Tape· 4 shared J. Sufi· 3 shared X. Qin· 3 shared C. Nattress· 2 shared A. Kanouta· 1 shared A. Southern Navarrete· 1 shared A. Tong· 1 shared B. Draper· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCancer Biology

C. J. Tape

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

J. Deng, T. Pan, Y. Hong, Z. Liu, X. Zhou, Z. An, L. Li, G. Alfano, G. Li, L. Dolcetti, R. Evans, J. M. Vicencio, P. Vlckova, Y. Chen, J. Monypenny, , T. Ng

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

bioRxiv · Aug 10, 2023 · PreprintCancer Biology

A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation

X. Qin, F. C. Rodriguez, J. Sufi, P. Vlckova, J. Claus, C. J. Tape

The paper maps how oncogenic mutations and microenvironmental signals co-regulate colonic stem cell fate through single-cell analysis of organoid cultures.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity

D. Fowler, M. Barisa, A. Southern Navarrete, C. Nattress, E. Hawkins, E. Vassalou, A. Kanouta, J. Counsell, E. M. Rota, P. Vlckova, B. Draper, C. J. Tape, K. Chester, J. Anderson, J. Fisher

OPS-γδ cells, engineered to secrete opsonins and stabilized IL15, show enhanced cytotoxicity and bystander activation for solid tumor control.

bioRxiv · Oct 23, 2022 · PreprintImmunology

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Single-Cell Signalling Analysis of Heterocellular Organoids

X. Qin, J. Sufi, P. Vlckova, P. Kyriakidou, S. E. Acton, V. S. W. Li, M. Nitz, C. J. Tape

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

bioRxiv · Nov 11, 2019Cell Biology