D. Hornburg

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

This study shows that amyloid-like aggregates impair lysosomal function in neurons by sequestering AP-31, leading to neurotoxicity.