Author

M. A. Chapman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Evolutionary Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

I. G. Walker· 3 shared C. J. Sundberg· 2 shared G. S. Anderson· 2 shared J. P. Roy· 2 shared S. M. Reitzner· 2 shared A. Aubareda· 1 shared A. Lundquist· 1 shared A. Mardinoglu· 1 shared

Activity by Year

2022-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

I. G. Walker

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Molecular profiling of high-level athlete skeletal muscle after acute exercise - a systems biology approach

S. M. Reitzner, E. B. Emanuelsson, M. Arif, B. Kaczkowski, A. T.-J. Kwon, A. Mardinoglu, E. Arner, M. A. Chapman, C. J. Sundberg

This study examines how acute exercise affects multi-omics profiles in skeletal muscle of trained and untrained individuals, revealing distinct metabolic and transcriptional responses based on training history and exercise type.

bioRxiv · Apr 11, 2023Physiology

Cell surface proteomics reveal a strategy for targeting myeloma through combinatorial targeting of TNFRSF8 and TMPRSS11E

G. S. Anderson, I. G. Walker, J. P. Roy, M. A. Chapman

The paper identifies AND-gate antigen combinations for myeloma targeting using proteomics and evaluates a dual-target CAR T-cell strategy.

bioRxiv · Apr 4, 2023 · PreprintCancer Biology

Targeting Myeloma Essential Genes using NOT Gated CAR- T Cells, a computational approach.

I. G. Walker, J. P. Roy, G. S. Anderson, J. A. Guerrero, M. A. Chapman

The paper explores using NOT-gated CAR-T cells to target essential but non-specific proteins in myeloma, showing that the transferrin receptor can be safely targeted with this approach.

bioRxiv · Apr 4, 2023Cancer Biology

A machine learning approach to predict drug-induced autoimmunity using transcriptional data.

G. L. Smith, I. G. Walker, A. Aubareda, M. A. Chapman

This paper uses an ensemble machine learning approach to predict drug-induced autoimmunity from transcriptional data, identifying dysregulated cell cycling as a potential mechanism.

bioRxiv · Apr 4, 2023 · PreprintPharmacology & Toxicology

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

M. Takahashi, T. So, K. Williamson, Z. Hosseini, K. Kania, M. Ruhle, T. Mann, M. J. Schujis, P. Coupland, D. Naisbitt, T. Y. F. Halim, P. A. Lyons, P. Lio, K. Okkenhaug, D. J. Adams, , J. E. D. Thaventhiran

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

bioRxiv · Mar 16, 2023Immunology

FiNuTyper: an automated deep learning-based platform for simultaneous fiber and nucleus type analysis in human skeletal muscle

A. Lundquist, E. Lazar, N. S. Han, E. Emanuelsson, S. M. Reitzner, M. A. Chapman, K. Alkass, H. Druid, S. Petri, C. J. Sundberg, O. Bergmann

FiNuTyper automates fiber and nucleus type analysis in human skeletal muscle, revealing gender- and muscle-related heterogeneity and adapting to pathological and other cell types.

bioRxiv · Dec 8, 2022 · PreprintCell Biology

Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays

M. V. Brovkina, M. A. Chapman, M. L. Holding, E. J. Clowney

The paper shows that AT-biased isochores and GC-poor promoters are associated with outward-looking gene clusters, and that these regions have distinct mutation and recombination patterns.

bioRxiv · Jul 13, 2022Evolutionary Biology

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

C. Pereira, D. Stalder, G. Anderson, A. S. Shun-Shion, J. Houghton, R. Antrobus, M. A. Chapman, D. J. Fazakerley, D. C. Gershlick

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

bioRxiv · May 26, 2022 · PreprintCell Biology