Author

A. K. Barczak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Jani· 2 shared J. Boucau· 2 shared N. Jain· 2 shared A. B. Balazs· 1 shared A. E. Hinman· 1 shared A. J. Martinot· 1 shared A. Marsh· 1 shared A. Romanov· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

C. Jani

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Vps18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages.

C. Jani, A. Marsh, P. Uchil, N. Jain, Z. R. Baskir, O. Glover, D. E. Root, J. G. Doench, A. K. Barczak

This study identifies Vps18 as a host factor critical for maintaining phagosomal membrane integrity in Mtb-infected macrophages, showing increased phagosomal damage and reduced antibiotic efficacy in its absence.

bioRxiv · Oct 1, 2023 · PreprintMicrobiology

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

E.-C. Wamhoff, L. Ronsard, J. Feldman, G. A. Knappe, B. M. Hauser, A. Romanov, E. Lam, K. St. Denis, J. Boucau, A. K. Barczak, A. B. Balazs, A. Schmidt, D. Lingwood, M. Bathe

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

bioRxiv · Aug 16, 2022Immunology

Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern

R. McNamara, J. S. Maron, H. L. Bertera, J. Boucau, V. Roy, A. K. Barczak, The Positives Study Staff, N. Franko, J. Z. Li, J. S. McLellan, M. Siedner, J. E. Lemieux, H. Chu, G. Alter

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

bioRxiv · Jun 19, 2022Immunology

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response.

A. E. Hinman, C. Jani, S. C. Pringle, W. R. Zhang, N. Jain, A. J. Martinot, A. K. Barczak

The paper identifies a late TLR2-dependent transcriptional response in macrophages to Mycobacterium tuberculosis mutants and shows how virulence factors interfere with this response to promote TB pathogenesis.

bioRxiv · Oct 6, 2021 · PreprintMicrobiology