Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
E.-C. Wamhoff, L. Ronsard, J. Feldman, G. A. Knappe, B. M. Hauser, A. Romanov, E. Lam, K. St. Denis, J. Boucau, A. K. Barczak, A. B. Balazs, A. Schmidt, D. Lingwood, M. Bathe
This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.
bioRxiv · Aug 16, 2022Immunology