Author

S. Giordano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Baum· 2 shared C. A. Kyratsous· 2 shared E. Wloga· 2 shared K. E. Pascal· 2 shared R. Copin· 2 shared A. Coppola· 1 shared A. J. Murphy· 1 shared A. Parvate· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiophysics

A. Baum

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

N. Zhang, L. Harbers, M. Simonetti, C. Diekmann, Q. Verron, E. Berrino, S. E. Bellomo, G. M. C. Longo, M. Ratz, N. Schultz, F. Tarish, P. Su, B. Han, W. Wang, S. Onorato, , N. Crosetto

bioRxiv · Nov 7, 2023Cancer Biology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

REGEN-COV protects against viral escape in preclinical and human studies

R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signaling

G. Cristinziano, M. Porru, D. Lamberti, S. Buglioni, F. Rollo, C. A. Amoreo, I. Manni, D. Giannarelli, C. Cristofoletti, G. Russo, M. J. Borad, G. L. Grazi, M. G. Diodoro, S. Giordano, M. Forcato, , O. Segatto

This paper develops FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma and shows that Erk signaling is essential for tumor growth, with double blockade of FF-Ras-Erk pathways improving therapeutic efficacy.

bioRxiv · May 20, 2020 · PreprintCancer Biology