D. S. Perlin

In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19

This study evaluates LCTG-002, a purified human milk sIgA product, showing it effectively reduces SARS-CoV-2 viral burden in mice.

Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness

This study investigates petite C. glabrata strains, showing they are echinocandin tolerant, induce inflammation, and have poor in vivo fitness, with low global prevalence.

Novel non hot spot modification in Fks1 of Candida auris confers echinocandin resistance

The paper identifies a novel FKS1 mutation in Candida auris associated with echinocandin resistance and demonstrates its functional impact using CRISPR/Cas9.

A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

Rare modification in the ergosterol biosynthesis pathway leads to amphotericin B resistance in Candida auris clinical isolates

The paper identifies a rare ERG6 genotype in Candida auris isolates that confers amphotericin B resistance.

Sex differences in cardio-pulmonary pathology of SARS-CoV2 infected and Trypanosoma cruzi co-infected mice

This study examines sex differences in cardio-pulmonary pathology in SARS-CoV-2 infected and Trypanosoma cruzi co-infected mice, showing sex-specific effects on adipose tissue and inflammation.

Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility

Multifactorial role of mitochondria in echinocandin tolerance revealed by transcriptome analysis of drug-tolerant cells

This paper identifies a unique transcriptional signature of echinocandin-tolerant Candida glabrata cells and reveals a multifactorial role of mitochondria in drug tolerance.

A non-canonical DNA damage checkpoint response in a major fungal pathogen

This study identifies a non-canonical DNA damage response in Candida glabrata that lacks Rad53 phosphorylation and S-phase arrest, leading to increased lethality and genetic instability.