Author

D. Tsygankov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. S. Zhovmer· 3 shared E. D. Tabdanov· 3 shared X. Ma· 3 shared A. Manning· 2 shared A. X. Cartagena-Rivera· 2 shared C. Smith· 2 shared R. Singh· 2 shared A. Nguyen· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

A. S. Zhovmer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch

A. S. Zhovmer, A. Manning, C. Smith, J. Wang, X. Ma, D. Tsygankov, N. V. Dokholyan, A. X. Cartagena-Rivera, R. Singh, E. D. Tabdanov

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

bioRxiv · Sep 26, 2023 · PreprintCell Biology

Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer

Y. Tagay, S. Kheirabadi, Z. Ataie, R. Singh, O. Prince, A. Nguyen, A. S. Zhovmer, X. Ma, A. Sheikhi, D. Tsygankov, E. D. Tabdanov

This study identifies dynein-powered locomotion as a complementary mechanism to actomyosin-driven movement in metastatic breast cancer cells, showing its necessity and sufficiency in 3D migration.

bioRxiv · Apr 4, 2023Cell Biology

Coordinated Regulation of Cdc42ep1, Actin, and Septin Filaments during Neural Crest Cell Migration

M. Kho, S. Hladyshau, D. Tsygankov, S. Nie

This study investigates how septin filaments regulate neural crest cell migration by interacting with actin stress fibers and requiring Cdc42ep1 for their function.

bioRxiv · Dec 4, 2022Cell Biology

Septins Provide Microenvironment Sensing and Cortical Actomyosin Partitioning in Motile Amoeboid T Lymphocytes

A. S. Zhovmer, A. Manning, C. Smith, P. J. Saez, X. Ma, D. Tsygankov, A. X. Cartagena-Rivera, R. K. Singh, E. D. Tabdanov

This paper identifies septins as key regulators of amoeboid motility in T cells by enabling microenvironment sensing and actomyosin partitioning through steric interactions with collagen fibers.

bioRxiv · Jan 18, 2022Biophysics

Correcting artifacts in ratiometric biosensor imaging; an improved approach for dividing noisy signals

D. J. Marston, S. Slattery, K. M. Hahn, D. Tsygankov

The paper introduces a method to correct artifacts in ratiometric biosensor imaging by subtracting a noise correction factor from the numerator only, improving accuracy in low signal-to-noise regions.

bioRxiv · Apr 13, 2021Cell Biology