Author

E. D. Tabdanov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. S. Zhovmer· 4 shared A. Manning· 3 shared A. X. Cartagena-Rivera· 3 shared C. Smith· 3 shared D. Tsygankov· 3 shared X. Ma· 3 shared R. K. Singh· 2 shared R. Singh· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

A. S. Zhovmer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch

A. S. Zhovmer, A. Manning, C. Smith, J. Wang, X. Ma, D. Tsygankov, N. V. Dokholyan, A. X. Cartagena-Rivera, R. Singh, E. D. Tabdanov

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

bioRxiv · Sep 26, 2023 · PreprintCell Biology

Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer

Y. Tagay, S. Kheirabadi, Z. Ataie, R. Singh, O. Prince, A. Nguyen, A. S. Zhovmer, X. Ma, A. Sheikhi, D. Tsygankov, E. D. Tabdanov

This study identifies dynein-powered locomotion as a complementary mechanism to actomyosin-driven movement in metastatic breast cancer cells, showing its necessity and sufficiency in 3D migration.

bioRxiv · Apr 4, 2023Cell Biology

Cyclic Loading Induces Anabolic and Catabolic Gene Expression in ACLs in a Load-Dependent and Sex-Specific Manner

L. N. Paschall, S. Carrozzi, E. D. Tabdanov, A. Dhawan, S. Szczesny

This study shows cyclic loading induces sex-specific anabolic and catabolic gene expression in ACLs, with male ACLs responding to lower loads and female ACLs downregulating remodeling genes across all loads.

bioRxiv · Nov 11, 2022Bioengineering

Septins Provide Microenvironment Sensing and Cortical Actomyosin Partitioning in Motile Amoeboid T Lymphocytes

A. S. Zhovmer, A. Manning, C. Smith, P. J. Saez, X. Ma, D. Tsygankov, A. X. Cartagena-Rivera, R. K. Singh, E. D. Tabdanov

This paper identifies septins as key regulators of amoeboid motility in T cells by enabling microenvironment sensing and actomyosin partitioning through steric interactions with collagen fibers.

bioRxiv · Jan 18, 2022Biophysics

Mechanical counterbalance of kinesin and dynein motors in microtubular network regulates cell mechanics, 3D architecture, and mechanosensing

A. S. Zhovmer, A. Manning, C. Smith, J. B. Hayes, D. T. Burnette, A. X. Cartagena-Rivera, R. K. Singh, E. D. Tabdanov

The paper shows dynein and kinesin motors balance microtubule network mechanics, affecting cell shape, adhesion, and mechanosensing through opposing actions on microtubule organization.

bioRxiv · May 25, 2021Biophysics

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

E. D. Tabdanov, N. J. Rodriguez-Merced, A. Cartagena-Rivera, V. Puram, M. Callaway, E. Ensminger, E. Pomeroy, K. Yamamoto, W. S. Lahr, B. R. Webber, B. Moriarity, A. Zhovmer, P. Provenzano

This study engineers T cells to improve 3D migration through tumor microenvironments by manipulating microtubule stability and contractility, showing enhanced migration in 3D matrices and tumors.

bioRxiv · Apr 21, 2020Cancer Biology