Author

N. A. Leu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. J. Lengner· 2 shared M. S. Kim· 2 shared N. Li· 2 shared Y. Tian· 2 shared Z. Cramer· 2 shared A. August· 1 shared A. Klochkova· 1 shared A. T. Tang· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

C. J. Lengner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

J. Y. Chotiner, N. A. Leu, F. Yang, I. G. Cossu, Y. Guan, H. Lin, P. J. Wang

This study shows TRIP13 localizes to synapsed chromosomes and is a dosage-sensitive regulator of meiosis, with loss leading to sterility and meiotic defects.

bioRxiv · Sep 25, 2023Cell Biology

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

Z. Cramer, X. Wang, N. A. Leu, K. Monaghan, J. H. Rhoades, Y. Tian, J. Rico, D. Mendez, R. Petroni, M. S. Kim, R. Matsuda, M. F. Carrera, I. E. Brodsky, N. Li, C. J. Lengner, M. A. Blanco

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

bioRxiv · Aug 3, 2023 · PreprintCancer Biology

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

S. Gao, A. T. Tang, M. Wang, D. W. Buchholz, B. Imbiakha, J. Yang, X. Chen, P. Hewins, P. Mericko-Ishizuka, N. A. Leu, S. Sterling, A. August, K. Jurado, E. Morrisey, H. Aguilar-Carreno, M. L. Kahn

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

bioRxiv · Jul 24, 2023 · PreprintPathology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology