Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity
M. T. H. Hrithrik, D.-H. Lee, N. Singh, A. Vik, B. Hammock, Y. Kim
This study investigates the role of EpOMEs and DiHOMEs in insect immune resolution, showing EpOMEs suppress immune responses while DiHOMEs enhance antimicrobial peptide expression, and their dysregulation increases susceptibility to pathogens.
bioRxiv · Jul 7, 2023 · PreprintImmunology