EZH2-driven immune evasion at disease presentation defines atargetable high-risk subset of acute leukemia exemplified byt(16;21) FUS::ERG AML
Nathaniel J. Buteyn, Samantha J LaMantia, Connor G Burke, Vincent J Sartori, Yizhou Peter Huang, Colton Dysart, Eve Deering-Gardner, Zachary J. DeBruine, Dahlya Kamarudin, Darrell P. Chandler, Alexander C. Monovich, Monika W. Perez, Joanna S. Yi, Rhonda E. Ries, Todd A. Alonzo, , Timothy Junius Triche
This paper identifies an EZH2-driven immune evasion phenotype in FUS::ERG AML that is reversible with tazemetostat, offering a potential targeted therapy for high-risk acute leukemia.
Blood Neoplasia · Sep 1, 2026Peer-reviewedCancer Biology