Christine N. Isaguirre

Reducing background ion burden in tributylamine ion-pairing LC-MS improves signal intensity and feature coverage in metabolomics

This study improves LC-MS metabolomics by reducing background ion burden from tributylamine, enhancing signal intensity and feature coverage across multiple biological samples.

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

The paper identifies group II p21-activated kinases as regulators of α-synucleinopathy by linking network vulnerability analysis to gene expression and pharmacological interventions.

A noncanonical polyamine from bacteria antagonizes animal mitochondrial function

This study identifies N1-APA, a noncanonical polyamine produced by bacteria, as a bioactive metabolite that antagonizes animal mitochondrial function and macrophage activation.

Single-embryo metabolomics reveals developmental metabolism in the early Drosophila embryo

This study develops a single-embryo metabolomics method to analyze metabolic and transcriptional changes in early Drosophila embryos with high temporal resolution.

Combined single-sample metabolomics and RNAseq reveals a hepatic pyrimidine metabolic response to acute viral infection

This study integrates metabolomics and RNAseq from the same liver samples to show that prior metabolite extraction does not harm RNAseq quality and reveals pyrimidine metabolism as a key pathway in acute viral infection.