Cancer BiologyNature CommunicationsPeer-reviewed
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda…·Marcel A.T.M. van Vugt
This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.
8 citations