Author

Jay Z. Yin

Mount Sinai Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander van OudenaardeniD· 1 shared Clara BonnetiD· 1 shared Daniel DurocheriD· 1 shared Daniëlle Bianchi· 1 shared Femke J. BakkeriD· 1 shared Frank SicheriiD· 1 shared H. Rudolf de BoeriD· 1 shared Jeroen van den BergiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander van OudenaardenORCID

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1 paper

Recent·Most cited

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael A. VanInsberghe, Marieke Everts, Femke J. Bakker, H. Rudolf de Boer, Nathalie Moatti, Nicole Hustedt, Jay Z. Yin, Lisa Hoeg, Matthew Leibovitch, , Marcel A.T.M. van Vugt

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

Nature Communications · Nov 24, 2025Peer-reviewedCancer Biology