Darrick R. Gates

Bacterial metabolites alter the consequences of reduced insulin signaling in C. elegans via increasing the expression of the acid sphingomyelinase asm-3.

This study shows that bacterial metabolites affect insulin signaling in C. elegans by altering acid sphingomyelinase expression.

Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans

This study identifies Massetolide F, a bacterial cyclic lipopeptide, as a molecule that suppresses dauer arrest in C. elegans by inducing acid sphingomyelinase expression.

Oocyte mitochondria link maternal environment to offspring phenotype

The paper identifies a role for oocyte mitochondrial electron transport chain remodeling in linking maternal environment to offspring metabolism and survival.

A noncanonical polyamine from bacteria antagonizes animal mitochondrial function

This study identifies N1-APA, a noncanonical polyamine produced by bacteria, as a bioactive metabolite that antagonizes animal mitochondrial function and macrophage activation.