Tie2 signaling in the tumor microenvironment orchestrates breast cancer cell dissemination through TMEM doorways
Camille L. Duran, Chinmay R. Surve, Prachiben P. Patel, Jack Hirsch, Jiufeng Li, Xianjun Ye, Nicole D. Barth, Xiaoming Chen, Suryansh Shukla, George S. Karagiannis, John C. McAuliffe, David Entenberg, Dianne Cox, John S. Condeelis, Maja H. Oktay
This study identifies macrophage Tie2 signaling as critical for TMEM doorway-mediated vascular permeability and metastatic dissemination in breast cancer.
bioRxiv · Apr 29, 2026 · PreprintCancer Biology