Diego A. Pizzagalli

Changes in anterior cingulate connectivity associated with response to antidepressant treatment for major depressive disorder

This study examines changes in anterior cingulate cortex connectivity in response to antidepressant treatment in MDD patients, finding distinct patterns associated with treatment response and remission.

Glutamatergic and Redox Abnormalities in Major Depressive Disorder: Links to Childhood Maltreatment and Perceived Stress

The paper examines associations between mPFC glutamatergic metabolites, redox balance, childhood maltreatment, and perceived stress in women with and without MDD.

Acute stress reorganizes pregenual cingulate and subthalamic coupling to approach-avoidance decisions in remitted depression

This study shows that acute stress reorganizes neural coupling in rMDD patients during decision-making, predicting future depressive symptoms.

Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics

In awake mice, psilocybin changed burst firing rather than mean firing rate across thalamus and hippocampus. Ketanserin pretreatment abolished most burst effects, but EEG power and firing-rate changes persisted.

Nociceptin/Orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli

This study examines how NOP receptor agonism affects behavioral and neural responses to aversive stimuli in squirrel monkeys, finding reduced fear responses and altered brain connectivity.

Nociceptin receptor and ligand in Alzheimer's disease:Implications for psychiatric symptoms and circadianregulation

This study examines PNOC and OPRL1 expression in Alzheimer's disease, finding sex differences and associations with psychiatric symptoms and circadian disruption.

Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across Species

This study shows that chronic stress alters Pnoc expression in reward-related brain regions and that NOPR antagonism improves reward learning and motivation in animals and humans.

Test-Retest Reliability and repeatability of Behavioral and Electrophysiological Markers in an Eriksen Flanker Task

The paper evaluates test-retest reliability and repeatability of behavioral and electrophysiological markers of cognitive control using the Eriksen Flanker Task in healthy individuals.

A mesocorticolimbic signature of pleasure in the human brain

This study identifies a human brain signature of pleasure using fMRI, showing it is sensitive to pleasant tastes and humor, and linked to opioid receptor activity.

Using diffusion MRI data acquired with ultra-high gradients to improve tractography in routine-quality data

This study improves automated white-matter tractography in lower-quality diffusion MRI data by training on high-quality Connectom data and manually annotated pathways.

Glutamatergic adaptation to stress in medial prefrontal cortex underlies risk and resilience for pessimistic beliefs

The paper examines stress-induced changes in mPFC glutamate using MRS in humans and finds disrupted glutamatergic adaptation in MDD associated with pessimistic beliefs.

Machine learning identifies large-scale reward-related activity modulated by dopaminergic enhancement in major depression

The paper uses machine learning to analyze fMRI data and identifies reward-related brain activity changes in MDD patients after dopaminergic enhancement.

Functional connectomics of affective and psychotic pathology

The paper examines functional connectomes across psychiatric diagnoses, finding common disruptions in network function across different pathologies and severity scaling, while psychotic symptoms show distinct disruptions.