The paper examines associations between mPFC glutamatergic metabolites, redox balance, childhood maltreatment, and perceived stress in women with and without MDD.

bioRxiv · Oct 30, 2026 · PreprintNeuroscience

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Y. Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue‐Ann Mok, , Li Gan

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

Nature Communications · Apr 12, 2022Peer-reviewedNeuroscience

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

Lihong Zhan, Grietje Krabbe, Fei Du, Ian Richard Jones, Meredith C. Reichert, Maria A. Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten A. Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian L. West, Li Gan

This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.

PLoS Biology · Feb 8, 2019Peer-reviewedNeuroscience