Author

E. Callen

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. G. Guzman· 1 shared A. G. Martell· 1 shared A. Nussenzweig· 1 shared A. Schreuder· 1 shared A. Tovy· 1 shared André NussenzweigiD· 1 shared Arne van HoeckiD· 1 shared B. B. de Vries· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. G. Guzman

Mutual co-authors in cluster

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2 papers

Recent·Most cited

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

L. Zhang, J. I. Hsu, E. D. Braekeleer, C.-w. Chen, T. D. Patel, A. G. Martell, A. G. Guzman, K. Wohlan, S. M. Waldvogel, H. Urya, A. Tovy, E. Callen, R. L. Murdaugh, R. U. Richard, S. Jansen, , M. A. Goodell

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

bioRxiv · Aug 31, 2023Cancer Biology

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

Bert van de Kooij, A. Schreuder, Raphael Pavani, Veronica Garzero, Arne van Hoeck, Marta San Martín Alonso, Dana Koerse, Tiemen J. Wendel, E. Callen, J. Boom, Hailiang Mei, Edwin P. J. G. Cuppen, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer

This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.

bioRxiv · Feb 24, 2023 · PreprintMolecular Biology