Author

A. Nussenzweig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:genetic perturbation / CRISPR· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

D. Zong· 3 shared A. Bennett· 1 shared A. G. Guzman· 1 shared A. G. Martell· 1 shared A. Tighe· 1 shared A. Tovy· 1 shared A. Tubbs· 1 shared A. V. Pankajam· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

D. Zong

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

L. Zhang, J. I. Hsu, E. D. Braekeleer, C.-w. Chen, T. D. Patel, A. G. Martell, A. G. Guzman, K. Wohlan, S. M. Waldvogel, H. Urya, A. Tovy, E. Callen, R. L. Murdaugh, R. U. Richard, S. Jansen, , M. A. Goodell

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

bioRxiv · Aug 31, 2023Cancer Biology

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

D. Zong, N. C. Koussa, J. A. Cornwell, A. V. Pankajam, M. Kruhlak, N. Wong, R. Chari, S. D. Cappell, A. Nussenzweig

This study maps the cellular response to WRN loss in MSI-H cancers, showing DNA damage accumulation and cell death, and suggests dual targeting of WRN and ATR as a therapeutic strategy.

bioRxiv · Jul 28, 2023Cancer Biology

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

B.-R. Chen, Y. Wang, A. Tubbs, D. Zong, F. Fowler, N. Zolnerowich, W. Wu, A. Bennett, C.-C. Chen, W. Feng, A. Nussenzweig, J. Tyler, B. P. Sleckman

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

bioRxiv · Apr 21, 2021Cell Biology

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

D. Bronder, D. Wangsa, D. Zong, T. J. Meyer, R. Wardenaar, P. Minshall, A. Tighe, D. Hirsch, K. Heselmeyer-Haddad, L. Nelson, D. Spierings, J. C. McGrail, M. Cam, A. Nussenzweig, F. Foijer, , S. S. Taylor

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

bioRxiv · Mar 12, 2021Cancer Biology