Author

E. d'Amico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Musacchio· 3 shared S. Wohlgemuth· 3 shared V. Cmentowski· 3 shared G. Ciossani· 2 shared I. R. Vetter· 2 shared S. Maffini· 2 shared A. Brockmeyer· 1 shared A. P. Carter· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

A. Musacchio

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A mechanism that integrates microtubule motors of opposite polarity at the kinetochore corona

V. Cmentowski, E. D'Amico, G. Ciossani, S. Wohlgemuth, M. Owa, B. D. Dynlacht, A. Musacchio

The paper identifies CENP-E's role in regulating DD kinetochore loading through the corona scaffold, ensuring coordinated bidirectional transport.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

E. d'Amico, M. Ud Din Ahmad, V. Cmentowski, M. Girbig, F. Mueller, S. Wohlgemuth, A. Brockmeyer, S. Maffini, P. Janning, I. R. Vetter, A. P. Carter, A. Perrakis, A. Musacchio

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

bioRxiv · Feb 2, 2022Biochemistry

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

T. Raisch, G. Ciossani, E. d'Amico, V. Cmentowski, S. Carmignani, S. Maffini, F. Merino, S. Wohlgemuth, I. R. Vetter, S. Raunser, A. Musacchio

The paper reports the structure of the RZZ complex and demonstrates the molecular mechanism of corona assembly at human kinetochores using cryo-EM and in vitro assays.

bioRxiv · Dec 3, 2021Biochemistry