Author

B. W. Wren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2

Frequent Co-Authors

B. Lehri· 3 shared F. Nasher· 3 shared N. Dorrell· 3 shared O. Gundogdu· 3 shared S. Abouelhadid· 3 shared A. Elmi· 2 shared A. McKenna· 2 shared A. Richmond· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

B. Lehri

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

A platform for the recombinant production of Group A Streptococcus glycoconjugate vaccines

S. Ajay Castro, I. J. Passmore, D. Ndeh, H. A. Shaw, A. Ruda, K. Burns, S. Thomson, R. Nagar, K. Alagesan, K. Lucas, S. Abouelhadid, M. Reglinski, U. Schwarz- Linek, F. Mawas, G. Widmalm, , H. C. Dorfmueller

This study develops a platform for recombinant production of Group A Streptococcus glycoconjugate vaccines using E. coli, confirming their structural integrity and immunogenicity in animal models.

bioRxiv · Mar 1, 2024Microbiology

Understanding Campylobacter coli isolates from the Vietnamese meat production network; a pilot study

B. Lehri, G. Navoly, A. Corser, F. Nasher, S. Willcocks, P. T. Ngoc, B. W. Wren, L. Q. Huong, R. A. Stabler

This study characterizes seven Campylobacter coli strains from Vietnam, revealing high antimicrobial resistance and virulence, and highlights their global spread.

bioRxiv · Nov 10, 2023 · PreprintMicrobiology

Survival of Campylobacter jejuni in Acanthamoebae castellanii provides mechanistic insight into host pathogen interactions.

F. Nasher, B. Lehri, M. F. Horney, R. a. Stabler, B. W. Wren

This study shows that Campylobacter jejuni can survive inside Acanthamoebae castellanii, using similar mechanisms as in warm-blooded hosts, suggesting amoebae as transient hosts for persistence and transmission.

bioRxiv · Jul 26, 2022 · PreprintMicrobiology

Campylobacter jejuni modulates reactive oxygen species production and NADPH oxidase 1 expression in human intestinal epithelial cells

G. Hong, C. Davies, Z. Omole, J. Liaw, A. D. Grabowska, B. Canonico, N. Corcionivoshi, B. W. Wren, N. Dorrell, A. Elmi, O. Gundogdu

This study shows Campylobacter jejuni modulates ROS production and NADPH oxidase 1 expression in human intestinal epithelial cells, affecting its ability to invade and survive.

bioRxiv · Mar 4, 2022Microbiology

Development of a novel glycoengineering platform for the rapid production of conjugate vaccines.

S. Abouelhadid, E. Atkins, E. Kay, I. Passmore, S. J. North, B. Lehri, P. Hitchen, E. Bakke, M. Rahman, J. Bosse, Y. Li, V. S. Terra, P. Langford, A. Dell, B. W. Wren, J. Cuccui

This paper develops a novel glycoengineering platform, MAGIC, which increases glycoconjugate yield and enables vaccine development in genetically intractable bacteria.

bioRxiv · Nov 25, 2021Microbiology

Survival of Campylobacter jejuni in Amoebae enhances subsequent invasion of mammalian cells

F. Nasher, B. W. Wren

This study shows that C. jejuni surviving in Acanthamoeba increases its invasiveness into mammalian cells and re-entry into amoebae.

bioRxiv · Nov 25, 2021Microbiology

Probing differences in gene essentiality between the human and animal adapted lineages of the Mycobacterium tuberculosis complex using TnSeq

A. J. Gibson, I. J. Passmore, V. Faulkner, D. Xia, I. Nobeli, J. Stiens, S. Willcocks, D. Werling, B. Villarreal-Ramos, B. W. Wren, S. L. Kendall

This study compares gene essentiality between Mycobacterium bovis and Mycobacterium tuberculosis using transposon sequencing and CRISPRi, finding species-specific differences in essential genes and their functional roles.

bioRxiv · Sep 21, 2021Microbiology

Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter

A. McKenna, U. Z. Ijaz, C. Kelly, M. Linton, W. T. Sloan, B. D. Green, U. Lavery, N. Dorrell, B. W. Wren, A. Richmond, N. Corcionivoschi, O. Gundogdu

This study examines how industrial chicken production system parameters affect gut microbiome composition and Campylobacter presence, identifying links between environmental factors, microbial dynamics, and performance metrics.

bioRxiv · May 10, 2020Microbiology

Domestication of Campylobacter jejuni NCTC 11168

B. Pascoe, L. K. Williams, J. K. Calland, G. Meric, M. D. Hitchings, M. Dyer, J. Ryder, S. Shaw, B. S. Lopes, C. Chintoan-Uta, E. Allan, A. Vidal, C. Fearnley, P. Everest, J. A. Pachebat, , S. K. Sheppard

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

bioRxiv · Apr 18, 2019Microbiology

N-linked glycans confer protein stability and modulate multidrug efflux pump assembly in Campylobacter jejuni

S. Abouelhadid, J. Raynes, T. T. T. Bui, J. Cuccui, B. W. Wren

bioRxiv · Mar 21, 2019 · PreprintBiochemistry

Comprehensive longitudinal microbiome analysis of the chicken cecum reveals a shift from competitive to environmental drivers and a window of opportunity for Campylobacter

U. Z. Ijaz, L. Sivaloganathan, A. Mckenna, A. Richmond, C. Kelly, M. Linton, A. Stratakos, U. Lavery, A. Elmi, B. W. Wren, N. Dorrell, N. Corcionivoschi, O. Gundogdu

This study tracks the chicken cecum microbiome from day 3 to 35, identifying a shift in microbial drivers and a window for Campylobacter appearance.

bioRxiv · Jun 11, 2018Microbiology