Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection
K. Santoni, D. Pericat, M. Pinilla, S. Bagayoko, A. Hessel, S. A. Leon-Ycaza, E. Bellard, S. Mazeres, E. Doz-Deblauwe, N. Winter, C. Paget, J.-P. Girard, C. Cougoule, R. Poincloux, M. Lamkanfi, , R. Planes
This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.
bioRxiv · Jun 28, 2021 · PreprintImmunology