R. Poincloux

The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics.

This study shows that ezrin, radixin, and moesin are not required for macrophage migration or actin cortex mechanics, challenging their universal importance in these processes.

Specialized actin nanoscale layers control focal adhesion turnover

The paper identifies two new nanoscale actin layers in focal adhesions, showing their distinct roles in adhesion maturation and disassembly through Tpm1.6 and Tpm3.2.

Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

This study uses advanced microscopy to reveal the nanoscale organization of actin cores in human osteoclast sealing zones, showing localized synchronization and coordination via actinin1 filaments.

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

Elasticity of dense actin networks produces nanonewton protrusive forces

The paper investigates how dense actin networks in podosomes generate protrusive forces by combining cryo-electron tomography and theoretical modeling.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

HIV-1-infected human macrophages, by secreting RANKL, contribute to enhanced osteoclastogenesis

This study shows HIV-1-infected macrophages secrete RANKL, promoting osteoclast precursor migration and contributing to bone degradation in HIV-1 patients.

Super-resolved live-cell imaging using Random Illumination Microscopy

This paper introduces Random Illumination Microscopy (RIM), a super-resolution technique that achieves high-resolution, low-toxicity, and fast imaging for live-cell studies.

Genetic engineering of hoxb8 immortalized hematopoietic progenitors: a potent tool to study macrophage tissue migration

The paper validates ER-Hoxb8-immortalized hematopoietic progenitors combined with CRISPR/Cas9 as a tool to study macrophage migration and functionality.