RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation
R. Spencer-Smith, E. M. Terrell, C. Insinna, C. Agamasu, M. E. Wagner, D. A. Ritt, J. Stauffer, A. G. Stephen, D. K. Morrison
This study examines RASopathy mutations in the BRAF cysteine-rich domain, showing they increase BRAF activity by relieving autoinhibition and enhancing PS binding, with autoinhibition being the main factor affecting mutation severity.
bioRxiv · Oct 1, 2021Cell Biology