Author

K. M. Haigis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

C. W. Johnson· 2 shared A. Cameron· 1 shared A. G. Stephen· 1 shared A. Liu· 1 shared A. Protti· 1 shared A. Whitley· 1 shared B. Andreiuk· 1 shared B. Hunt· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. W. Johnson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vivo Imaging using Surface Enhanced Spatially Offset Raman Spectroscopy (SESORS): Balancing Sampling Frequency to Improve Overall Image Acquisition

F. Nicolson, B. Andreiuk, E. Lee, B. O'Donnell, A. Whitley, N. Riepl, D. Burkhart, A. Cameron, A. Protti, S. Rudder, J. Yang, S. Mabbott, K. M. Haigis

This paper introduces SESORRS, a technique combining SERRS and SORS for in vivo tumor imaging, showing improved SNR and faster acquisition of deep-seated tumor data.

bioRxiv · Sep 17, 2023Bioengineering

Allosteric regulation of switch-II controls K-Ras oncogenicity

M. H. Yang, T. H. Tran, B. Hunt, R. Agnor, C. W. Johnson, T. J. Waybright, J. A. Nowak, A. G. Stephen, D. K. Simanshu, K. M. Haigis

This study shows that the K104Q mutation reduces oncogenic K-Ras activity in vivo by disrupting GEF-mediated nucleotide exchange and stabilizing switch-II helix through an allosteric network.

bioRxiv · Sep 20, 2022 · PreprintCancer Biology

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry