Author

J. Lakhani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

E. A. Geffken· 2 shared H.-S. Seo· 2 shared K. Song· 2 shared S. Dhe-Paganon· 2 shared A. Liu· 1 shared A. S. Boghossian· 1 shared C. B. Marshall· 1 shared C. Mattos· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

E. A. Geffken

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

bioRxiv · May 10, 2022Cancer Biology

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry

Adaptive laboratory evolution triggers pathogen-dependent broad-spectrum antimicrobial potency in Streptomyces

D. Harwani, J. Begani, J. Lakhani

This study uses adaptive laboratory evolution to enhance antimicrobial potency in a Streptomyces strain, showing that quadriculture competition leads to the highest antimicrobial activity against bacterial pathogens and MDR E. coli.

bioRxiv · Jan 20, 2021Microbiology