E. Ryder

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

The paper assesses CRISPR-Cas9 off-target effects in gene-edited mice using trio sequencing and finds no unexpected off-target activity.