Author

E. Speranza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. N. Germain· 3 shared A. Gola· 2 shared A. J. Radtke· 2 shared A. Okumura· 2 shared B. N. Williamson· 2 shared C. J. Chu· 2 shared C. Shaia· 2 shared E. de Wit· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

R. N. Germain

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rebalancing Viral and Immune Damage versus Tissue Repair Prevents Death from Lethal Influenza Infection

H. Ichise, E. Speranza, F. La Russa, T. Z. Veres, C. J. Chu, A. Gola, R. N. Germain

The paper shows that balancing viral damage, immune response, and tissue repair can prevent death from lethal influenza by combining antiviral drugs with strategies to enhance epithelial repair.

bioRxiv · Jul 4, 2024Immunology

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

A. J. Radtke, E. Postovalova, A. Varlamova, A. Bagaev, M. Sorokina, O. Kudryashova, M. Meerson, M. Polyakova, I. Galkin, V. Svekolkin, S. Isaev, G. Perelman, Y. Lozinsky, Z. Yaniv, B. C. Lowekamp, , R. N. Germain

This study creates a multi-scale, multiomic atlas of human normal and follicular lymphoma lymph nodes to identify tumor-specific features and microenvironmental patterns associated with early relapse.

bioRxiv · Jun 3, 2022Cancer Biology

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

E. Speranza, J. N. Purushotham, J. R. Port, B. Schwarz, M. Flagg, B. N. Williamson, F. Feldmann, M. Singh, L. Perez-Perez, G. L. Sturdevant, L. M. Roberts, A. Carmody, J. E. Schulz, N. van Doremalen, A. Okumura, , E. de Wit

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

bioRxiv · Sep 8, 2021Immunology

IBEX: A versatile multi-plex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

A. J. Radtke, E. Kandov, B. Lowekamp, E. Speranza, C. J. Chu, A. Gola, N. Thakur, R. Shih, L. Yao, Z. R. Yaniv, R. T. Beuschel, J. Kabat, J. Croteau, J. Davis, J. M. Hernandez, R. N. Germain

IBEX enables high-resolution, multi-plex imaging of over 65 parameters in tissue sections without degradation, supporting spatial analysis and integration with other technologies.

bioRxiv · Nov 20, 2020Immunology

SARS-CoV-2 infection dynamics in lungs of African green monkeys

E. Speranza, B. N. Williamson, F. Feldmann, G. L. Sturdevant, L. Perez-Perez, K. Mead-White, B. J. Smith, J. Lovaglio, C. Martens, V. Munster, A. Okumura, C. Shaia, H. Feldmann, S. M. Best, E. de Wit

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

bioRxiv · Aug 20, 2020Microbiology