Author

J. R. Port

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 11 Organism:mouse· 8 Assay:proteomics· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. K. Yinda· 7 shared J. E. Schulz· 7 shared N. van Doremalen· 7 shared V. Munster· 7 shared V. A. Avanzato· 5 shared V. J. Munster· 5 shared C. Shaia· 4 shared M. G. Holbrook· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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7 shared papersMicrobiology

C. K. Yinda

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

A bivalent Adenovirus-Vectored Vaccine induces a measurable humoral response, but does not protect cynomolgus macaques against a lethal challenge with Sudan virus

S. van Tol, P. Fletcher, F. Feldmann, R. K. Mukesh, J. R. Port, S. Gallogly, J. E. Schulz, J. F. Roderick, R. Makinson, A. Carmody, L. Myers, J. Lovaglio, B. J. Smith, A. Okumura, C. Shaia, , N. van Doremalen

This study evaluates a bivalent Adenovirus-Vectored Vaccine in cynomolgus macaques against Sudan virus, finding it induces humoral responses but does not confer protection against lethal challenge.

bioRxiv · Oct 20, 2023Microbiology

Stability of mpox (monkeypox) virus in bodily fluids and wastewater

C. K. Yinda, D. H. Morris, R. Fischer, S. Gallogly, Z. Weishampel, J. R. Port, T. Bushmaker, J. E. Schulz, K. Bibby, N. van Doremalen, J. O. Lloyd-Smith, V. Munster

This study investigates the stability of MPXV in bodily fluids and wastewater, finding it remains infectious in protein-rich fluids and is effectively neutralized by chlorination.

bioRxiv · May 9, 2023 · PreprintMicrobiology

Rectal and vaginal challenge with mpox virus increases virus dissemination and contact transmission compared to skin challenge in the multimammate rat (Mastomys natalensis)

J. R. Port, J. C. Riopelle, S. G. Smith, L. Myers, M. C. Lewis, S. Gallogly, A. Okumura, J. E. Schukz, R. Rosenke, J. Prado-Smith, A. Carmody, S. Bane, B. J. Smith, G. Saturday, H. Feldmann, , V. J. Munster

This study shows that rectal and vaginal mpox virus inoculation in rats leads to more virus shedding and contact transmission compared to skin inoculation.

bioRxiv · May 7, 2023 · PreprintMicrobiology

Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster

J. R. Port, D. H. Morris, J. C. Riopelle, C. K. Yinda, V. A. Avanzato, M. G. Holbrook, T. Bushmaker, J. E. Schulz, T. A. Saturday, K. Barbian, C. A. Russel, R. Perry-Gottschalk, C. I. Shaia, C. Martens, J. O. Lloyd-Smith, , V. J. Munster

This study investigates how SARS-CoV-2 infection affects airborne transmission in Syrian hamsters, finding that viral shedding and transmission efficiency vary by host and virus factors.

bioRxiv · Aug 15, 2022Microbiology

Infection- or vaccine mediated immunity reduces SARS-CoV-2 transmission, but increases competitiveness of Omicron in hamsters

J. R. Port, C. K. Yinda, J. C. Riopelle, Z. A. Weishampel, T. A. Saturday, V. A. Avanzato, J. E. Schukz, M. G. Holbrook, K. Barbian, R. Perry-Gottschalk, E. Haddock, C. Martens, C. I. Shaia, T. Lambe, S. C. Gilbert, , V. J. Munster

This study shows that vaccination and prior infection reduce SARS-CoV-2 transmission but increase Omicron competitiveness in hamsters compared to Delta.

bioRxiv · Jul 29, 2022 · PreprintMicrobiology

Severe acute respiratory disease in American mink (Neovison vison) experimentally infected with SARS-CoV-2

D. R. Adney, J. Lovaglio, J. E. Schulz, C. K. Yinda, V. A. Avanzato, E. Haddock, J. R. Port, M. Holbrook, P. W. Hanley, G. Saturday, D. Scott, J. R. Spengler, C. Tansey, C. Cossaboom, N. Wendling, , V. J. Munster

This study shows that SARS-CoV-2 infected mink develop severe respiratory disease with features similar to severe acute respiratory disease in humans.

bioRxiv · Jan 20, 2022 · PreprintMicrobiology

UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

R. Fischer, J. R. Port, M. Holbrook, K. C. Yinda, M. Creusen, J. ter Stege, M. de Samber, V. Munster

This study shows UV-C light prevents airborne SARS-CoV-2 transmission between hamsters.

bioRxiv · Jan 10, 2022 · PreprintMicrobiology

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

E. Speranza, J. N. Purushotham, J. R. Port, B. Schwarz, M. Flagg, B. N. Williamson, F. Feldmann, M. Singh, L. Perez-Perez, G. L. Sturdevant, L. M. Roberts, A. Carmody, J. E. Schulz, N. van Doremalen, A. Okumura, , E. de Wit

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

bioRxiv · Sep 8, 2021Immunology

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

T. Carroll, D. Fox, N. van Doremalen, E. Ball, M. K. Morris, A. Sotomayor-Gonzalez, V. Servellita, A. Rustagi, C. K. Yinda, L. Fritts, J. R. Port, Z.-M. Ma, M. Holbrook, J. Schulz, C. A. Blish, , C. J. Miller

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

bioRxiv · Aug 25, 2021Microbiology

Western diet increases COVID-19 disease severity in the Syrian hamster

J. R. Port, D. R. Adney, B. Schwarz, J. Schulz, D. E. Sturdevant, B. J. Smith, V. Avanzato, M. G. Holbrook, J. Purushotham, K. A. Stromberg, I. Leighton, C. Bosio, C. Shaia, V. Munster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

bioRxiv · Jun 17, 2021 · PreprintMicrobiology

SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters

J. R. Port, C. K. Yinda, I. Offei Owusu, M. Holbrook, R. J. Fischer, T. J. Bushmaker, V. A. Avanzato, J. E. Schulz, N. van Doremalen, C. Clancy, V. Munster

This study shows that airborne SARS-CoV-2 exposure causes more severe disease and efficient transmission in Syrian hamsters compared to fomite exposure.

bioRxiv · Dec 28, 2020Microbiology

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

C. K. Yinda, J. R. Port, T. J. Bushmaker, I. Offei Owusu, V. A. Avanzato, R. J. Fischer, J. E. Schulz, M. G. Holbrook, M. J. Hebner, R. Rosenke, T. Thomas, A. Marzi, S. M. Best, E. de Wit, C. Shaia, , V. Munster

This paper shows that K18-hACE2 mice develop severe respiratory disease upon SARS-CoV-2 infection, resembling human severe COVID-19 with lung pathology and systemic inflammation.

bioRxiv · Aug 11, 2020Microbiology