Author

L. Perez-Perez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:rat· 5 Organism:non-human primate· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:metabolomics· 1

Frequent Co-Authors

E. de Wit· 8 shared F. Feldmann· 8 shared J. Lovaglio· 8 shared A. Okumura· 7 shared N. van Doremalen· 6 shared P. Hanley· 6 shared V. Munster· 6 shared B. Williamson· 5 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

8 shared papersMicrobiology

E. de Wit

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure

R. Fischer, T. Bushmaker, B. N. Williamson, L. Perez-Perez, F. Feldmann, J. Lovaglio, D. Scott, G. Saturday, H. Feldmann, V. J. Munster, E. de Wit, N. van Doremalen

This study compares SARS-CoV-2 replication in rhesus macaques after intranasal inoculation or aerosol exposure, finding differences in respiratory tract involvement.

bioRxiv · Sep 11, 2023Microbiology

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

N. van Doremalen, M. Singh, T. Saturday, K. C. Yinda, L. Perez-Perez, W. F. Bohler, Z. Weishampel, M. Lewis, J. Schulz, B. Williamson, K. Meade-White, S. Gallogly, A. Okumura, F. Feldmann, J. Lovaglio, , K. Rosenke

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Science Advances · Nov 16, 2022Peer-reviewedMicrobiology

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

E. Speranza, J. N. Purushotham, J. R. Port, B. Schwarz, M. Flagg, B. N. Williamson, F. Feldmann, M. Singh, L. Perez-Perez, G. L. Sturdevant, L. M. Roberts, A. Carmody, J. E. Schulz, N. van Doremalen, A. Okumura, , E. de Wit

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

bioRxiv · Sep 8, 2021Immunology

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

V. Munster, M. Flagg, M. Singh, B. Williamson, F. Feldmann, L. Perez-Perez, B. Brumbaugh, M. Holbrook, D. Adney, A. Okumura, P. Hanley, B. Smith, J. Lovaglio, S. Anzick, C. Martens, , E. de Wit

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

bioRxiv · May 7, 2021Microbiology

SARS-CoV-2 infection dynamics in lungs of African green monkeys

E. Speranza, B. N. Williamson, F. Feldmann, G. L. Sturdevant, L. Perez-Perez, K. Mead-White, B. J. Smith, J. Lovaglio, C. Martens, V. Munster, A. Okumura, C. Shaia, H. Feldmann, S. M. Best, E. de Wit

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

bioRxiv · Aug 20, 2020Microbiology

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

K. Rosenke, M. Jarvis, F. Feldmann, B. Schwarz, A. Okumura, J. Lovaglio, G. Saturday, P. Hanley, K. Meade-White, B. Williamson, F. Hansen, L. Perez-Perez, S. Leventhal, T.-L. Tang-Huau, M. Nason, , H. Feldmann

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

bioRxiv · Jun 10, 2020 · PreprintPharmacology & Toxicology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

B. Williamson, F. Feldmann, B. Schwarz, K. Meade-White, D. Porter, J. Schulz, N. van Doremalen, I. Leighton, C. K. Yinda, L. Perez-Perez, A. Okumura, J. Lovaglio, P. Hanley, G. Saturday, C. Bosio, , E. de Wit

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

bioRxiv · Apr 15, 2020Microbiology