V. Munster

Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

This study demonstrates limited MERS-CoV transmission via aerosol, fomite, and direct contact in a transgenic human DPP4 mouse model.

Environmental Persistence and Disinfection of Lassa Virus

This study examines the environmental persistence of Lassa virus strains on surfaces and their inactivation by sodium hypochlorite.

Stability of mpox (monkeypox) virus in bodily fluids and wastewater

This study investigates the stability of MPXV in bodily fluids and wastewater, finding it remains infectious in protein-rich fluids and is effectively neutralized by chlorination.

Comparative aerosol and surface stability of SARS-CoV-2 Variants of Concern

This study compares aerosol and surface stability of SARS-CoV-2 variants, finding early VOCs more stable than WA1, but Delta and Omicron do not show increased stability, suggesting stability changes are not the main driver of transmissibility.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

This study identifies a monoclonal antibody, mAb92, that targets the Nipah virus fusion glycoprotein and provides complete protection in hamsters.

UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

This study shows UV-C light prevents airborne SARS-CoV-2 transmission between hamsters.

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2

This study shows that the B.1.1.7 variant of SARS-CoV-2 is more efficiently transmitted via aerosols than lineage A in Syrian hamsters.

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

ChAdOx1 NiV vaccination protects African green monkeys from lethal Nipah virus infection, preventing disease signs and viral replication.

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

This study evaluates the immunogenicity of a low-dose prime-boost mRNA vaccine in non-human primates, finding limited antibody and T cell responses in some animals.

Western diet increases COVID-19 disease severity in the Syrian hamster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters

This study shows that airborne SARS-CoV-2 exposure causes more severe disease and efficient transmission in Syrian hamsters compared to fomite exposure.

Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

The paper develops a mechanistic model to predict how temperature and humidity affect the inactivation rate of SARS-CoV-2 and other enveloped viruses.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

SARS-CoV-2 infection dynamics in lungs of African green monkeys

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

This paper shows that K18-hACE2 mice develop severe respiratory disease upon SARS-CoV-2 infection, resembling human severe COVID-19 with lung pathology and systemic inflammation.

The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

This study investigates the evolutionary history of ACE2 usage in sarbecoviruses, showing that ACE2 usage in SARS-CoV-1 and SARS-CoV-2 likely arose through recombination with SARS-CoV-1 relatives, not SARS-CoV-2.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

This study shows that SARS-CoV-2 causes respiratory disease in rhesus macaques with symptoms similar to human cases, including prolonged viral shedding.

Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV

The paper assesses receptor usage and cell entry for lineage B β-coronaviruses, including 2019-nCoV, showing protease processing as a barrier and confirming ACE2 as the receptor for 2019-nCoV.