E. Tajkhorshid

The paper presents a 2.6 Å structure of a CLC mutant, revealing a global conformational change that supports a unified transport mechanism for CLC proteins.

The paper investigates how a small molecule alters Sortilin's function, affecting ApoB and PCSK9 trafficking in liver cells and revealing a conserved mechanism in yeast.

This paper determines the structures of Aβ(1-42) tetramers and octamers in membrane-mimicking environments and identifies a new mechanism of membrane disruption via hydrophilic edge pores.

This study identifies three PI(4,5)P2 binding sites on ANO1 that allosterically regulate its Ca2+-activated Cl- channel gating through molecular dynamics and electrophysiology.

The paper uses molecular dynamics simulations to study the permeability of carboxysome shell pores to anionic molecules, confirming selective permeability to [Formula] over O2.

This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

The paper determines the structure of the AMPA receptor-TARP complex using cryo-EM, revealing activation and desensitization mechanisms.