Author

J. L. Schultze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2

Frequent Co-Authors

K. Haendler· 4 shared J. Schulte-Schrepping· 3 shared K. Bassler· 3 shared A. Schlitzer· 2 shared F. Ginhoux· 2 shared M. Becker· 2 shared A. Al Jawazneh· 1 shared A. Condino-Neto· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

K. Haendler

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

K. F. Budden, S. Shukla, K. L. Bowerman, S. L. Gellatly, D. L. A. Wood, N. Lachner, S. Idrees, V. Patel, A. F. Faiz, S. F. Rehman, C. Donovan, C. Alemao, S. Shen, K. S. Vanka, J. Mason, , P. M. Hansbro

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

bioRxiv · Oct 16, 2023 · PreprintPhysiology

Donor tissue-resident memory-like T and NK cells generate a transient peripheral chimerism in lung transplant recipients, potentially protective from chronic lung allograft dysfunction

R. Bellmas-Sanz, A.-M. Hitz, B. Wiegmann, J. F. Kuehne, E. Chichelnitskiy, T. S. Kapellos, K.-A. Blaesing, J. Keil, K. Beushausen, W. Sommer, K. Haendler, M. Becker, K. Bassler, L.-M. Horn, D. Jonigk, , C. S. Falk

Donor TRM-like T and NK cells create a temporary chimerism in lung transplant recipients, possibly reducing the risk of chronic lung allograft dysfunction.

bioRxiv · Jun 16, 2023 · PreprintImmunology

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

H. Theobald, D. Bejarano, N. Katzmarski, J. Haub, J. Schulte-Schrepping, J. Yu, K. Bassler, C. Osei-Sarpong, F. Piattini, L. Vornholz, X. Xu, S. Sheoran, A. Al Jawazneh, S. Chakarov, K. Haendler, , A. Schlitzer

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

bioRxiv · Sep 15, 2022Immunology

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

L. Cottone, L. Ligammari, H. J. Knowles, H.-M. Lee, S. Henderson, S. Bianco, C. Davies, S. Strauss, F. Amary, A. P. Leite, R. Tirabosco, K. Haendler, J. L. Schultze, J. Herrero, P. ODonnell, , A. M. Flanagan

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

bioRxiv · Dec 27, 2021Cancer Biology

Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

L. F. Schimke, A. H. Marques, G. C. Baiocchi, C. A. Prado, D. L. Fonseca, P. P. Freire, D. R. Placa, I. S. Filgueira, R. C. Salgado, G. Jansen-Marques, A. E. Oliveira, J. P. S. Peron, G. Cabral Miranda, J. A. M. Barbuto, N. O. S. Camara, , O. C. Marques

This study identifies a shared neutrophil activation signature between severe COVID-19 and other acute inflammatory conditions, suggesting common therapeutic targets.

bioRxiv · Jul 30, 2021Immunology

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation

M. Embgenbroich, H. J. van der Zande, L. Hussaarts, J. Schulte-Schrepping, L. R. Pelgrom, N. Garcia-Tardon, L. Schlautmann, I. Stoetzel, K. Handler, J. M. Lambooij, A. Zawistowska-Deniziak, L. Hoving, K. de Ruiter, M. Wijngaarden, H. Pijl, , S. Burgdorf

This study shows that soluble mannose receptor (sMR) promotes pro-inflammatory macrophage activation and metaflammation by inhibiting CD45 phosphatase activity, leading to metabolic dysfunctions in obesity.

bioRxiv · Sep 29, 2020 · PreprintImmunology

A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space

P. Guenther, B. Cirovic, K. Bassler, K. Haendler, M. Becker, C. A. Dutertre, V. Bigley, E. W. Newell, M. Collin, F. Ginhoux, A. Schlitzer, J. L. Schultze

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.

bioRxiv · Jun 3, 2019 · PreprintImmunology