Author

J. A. Mears

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Rochon· 2 shared A. B. Hjelmeland· 1 shared A. Hinton· 1 shared A. Lauko· 1 shared A. Marshall· 1 shared A. N. Hutson· 1 shared B. L. Bauer· 1 shared B. Loos· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

K. Rochon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Structure of the Drp1 Lattice on Membrane

R. Peng, K. Rochon, A. N. Hutson, S. Stagg, J. A. Mears

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

bioRxiv · Apr 4, 2024Biochemistry

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

K. Rochon, B. L. Bauer, N. A. Roethler, Y. Buckley, C.-C. Su, W. Huang, R. Ramachandran, M. S. K. Stoll, E. W. Yu, D. J. Taylor, J. A. Mears

This paper presents a cryo-EM structure of Drp1 dimer revealing conformational rearrangements that regulate its self-assembly and mitochondrial fission.

bioRxiv · Jun 22, 2023Cell Biology

DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

G. L. Robertson, S. N. Riffle, M. Patel, A. Marshall, H. Beasley, E. Garza-Lopez, J. Shao, Z. Vue, M. S. Stoll, S. de Wet, R. P. Theart, B. Loos, A. Hinton, J. A. Mears, V. Gama

This study investigates how DRP1 mutations affect mitochondrial and peroxisomal dynamics, leading to metabolic dysfunction and structural abnormalities in EMPF1 patient fibroblasts.

bioRxiv · Dec 31, 2021Cell Biology

Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity

D. C. Watson, D. Bayik, S. E. Williford, A. Lauko, Y. Zhou, G. Deshpande, J. Seder, J. A. Mears, F. Cheng, A. B. Hjelmeland, J. D. Lathia

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

bioRxiv · Sep 1, 2021Cancer Biology