Author

H. van der Wel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. M. West· 3 shared E. Gas-Pascual· 2 shared H. W. Kim· 2 shared M. Mandalasi· 2 shared A. Eletsky· 1 shared C. Agop-Nersesian· 1 shared C. West· 1 shared D. Thieker· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

C. M. West

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The GPI sidechain of Toxoplasma gondii prevents parasite pathogenesis

J. A. Alvarez, E. Gas-Pascual, S. Malhi, F. N. Njume, J. C. Sanchez-Arcila, H. van der Wel, Y. Zhao, G. Ceron, J. Posada, S. P. Souza, G. S. Yap, C. West, K. D. C. Jensen

This paper identifies and characterizes glycosyltransferases in Toxoplasma gondii that modify GPI sidechains, showing that their absence increases parasite virulence.

bioRxiv · Feb 21, 2024 · PreprintMicrobiology

The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii

G. Bandini, C. Agop-Nersesian, H. van der Wel, M. Mandalasi, H. Kim, C. M. West, J. Samuelson

This paper identifies TgSPY as the O-fucosyltransferase in Toxoplasma gondii, showing it modifies proteins but is not essential for growth, yet affects protein levels and virulence in mice.

bioRxiv · Aug 30, 2020Microbiology

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

M. Mandalasi, H. W. Kim, D. Thieker, M. O. Sheikh, E. Gas-Pascual, K. Rahman, P. Zhao, N. G. Daniel, H. van der Wel, T. H. Ichikawa, J. N. Glushka, L. Wells, R. J. Woods, Z. A. Wood, C. M. West

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

bioRxiv · Feb 2, 2020 · PreprintMicrobiology

Skp1 Dimerization Conceals its F-box Protein Binding Site

H. W. Kim, A. Eletsky, K. J. Gonzalez, H. van der Wel, E.-M. Strauch, J. H. Prestegard, C. M. West

This paper investigates how Skp1 dimerization hides its F-box protein binding site, showing that a mutation disrupts dimerization and allows Skp1 to bind F-box proteins.

bioRxiv · Jan 26, 2020Biochemistry