Author

W. Weissenhorn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:electronic health records· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

N. De Franceschi· 4 shared D. Guilligay· 3 shared N. Miguet· 3 shared P. Bassereau· 3 shared S. Maity· 3 shared C. Boscheron· 2 shared D. Fenel· 2 shared G. Schoehn· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCell Biology

N. De Franceschi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

An inducible ESCRT-III inhibition tool to control HIV-1 budding

H. Wang, B. Gallet, C. Moriscot, M. Pezet, C. Chatellard, J.-P. Kleman, H. Gottlinger, W. Weissenhorn, C. Boscheron

This paper develops a drug-inducible tool to inhibit HIV-1 budding by transiently stabilizing ESCRT-III components, showing varying effects on VLP release.

bioRxiv · Oct 16, 2023Microbiology

Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

K. Azad, D. Guilligay, C. Boscheron, S. Maity, N. De Franceschi, G. Sulbaran, G. Effantin, H. Wang, J.-P. Kleman, P. Bassereau, G. Schoehn, W. Roos, A. Desfosses, W. Weissenhorn

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

bioRxiv · Apr 12, 2022Cell Biology

The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC

A. Blanch Jover, N. De Franceschi, D. Fenel, W. Weissenhorn, C. Dekker

This study shows that CdvB1 forms filamentous polymers that are depolymerized by CdvC, and that polymerization and membrane binding are mutually exclusive.

bioRxiv · Oct 7, 2021 · PreprintBiochemistry

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

G. Sulbaran, P. Maisonnasse, A. Amen, D. Guilligay, N. Bosquet, J. A. Burger, M. Poniman, M. Buisson, S. D. Dylon, T. Naninck, J. Lemaitre, W. Gros, A.-S. Gallouet, R. Marlin, C. Bouillier, , W. Weissenhorn

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

bioRxiv · Jul 26, 2021Immunology

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

C. Caillat, D. Guilligay, J. Torralba, N. Friedrich, J. L. Nieva, A. Trkola, C. Chipot, F. Dehez, W. Weissenhorn

This paper presents the crystal structure of HIV-1 gp41 in a fusion intermediate state, revealing conformational plasticity and how antibodies block membrane fusion.

bioRxiv · Nov 12, 2020Microbiology

Human ESCRT-III Polymers Assemble on Positively Curved Membranes and Induce Helical Membrane Tube Formation

A. Bertin, N. de Franceschi, E. de la Mora, S. maity, N. Miguet, A. di Cicco, W. H. Roos, S. Mangenot, W. Weissenhorn, P. Bassereau

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.

bioRxiv · Nov 20, 2019Cell Biology

The ESCRT-III Isoforms CHMP2A And CHMP2B Display Different Effects On Membranes Upon Polymerization

M. Alqabandi, N. de Franceschi, N. Miguet, S. Maity, M. Bally, W. Roos, W. Weissenhorn, P. Bassereau, S. Mangenot

This study compares the membrane interactions of CHMP2A and CHMP2B, finding they have distinct lipid binding preferences and mechanical effects on membranes.

bioRxiv · Sep 3, 2019Biophysics

ILT7 activation and plasmacytoid dendritic cell response are governed by BST2 determinants that are structurally-distinct

M. G. Bego, N. Miguet, A. Laliberte, N. Aschman, F. Gerard, A. A. Merakos, W. Weissenhorn, E. A. Cohen

The paper identifies structurally distinct BST2 regions that govern ILT7 activation and pDC responses, showing how mutations in these regions affect immune signaling.

bioRxiv · Feb 21, 2019Immunology