Author

B. R. Stockwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Chavez· 2 shared A. Zask· 2 shared D. D. Ho· 2 shared F. Zandkarimi· 2 shared H. Liu· 2 shared M. S. Nair· 2 shared S. Iketani· 2 shared S. J. Hong· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. Chavez

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

J. Tschuck, V. Padmanabhan Nair, A. Galhoz, G. Ciceri, I. Rothenaigner, J. Tchieu, H.-M. Tai, B. R. Stockwell, L. Studer, M. P. Menden, M. Vincendeau, K. Hadian

This study shows that suppressing ferroptosis via antioxidants or vitamin A is necessary for proper neuronal development and laminar organization in cortical organoids.

bioRxiv · Apr 5, 2023 · PreprintCell Biology

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

M. A. Banu, A. Dovas, M. G. Argenziano, W. Zhao, H. Cuervo, D. M. Higgins, C. P. Sperring, B. Pereira, L. F. Ye, A. Mahajan, N. Humala, J. L. Furnari, P. S. Upadhyayula, F. Zandkarimi, T. T. Nguyen, , P. D. Canoll

The paper identifies a metabolic vulnerability in specific glioma cell states that can be targeted with GPX4 inhibitors to induce ferroptosis.

bioRxiv · Feb 22, 2023Cancer Biology

Multimodal mass spectrometry imaging reveals single-cell metabolic states in mammalian liver

H. Tian, P. R. Rajbhandari, J. Tarolli, A. M. Decker, T. V. Neelakantan, T. Angerer, F. Zandkarimi, J. Daniels, H. R. Remotti, G. Frache, N. Winograd, B. R. Stockwell

This paper develops a multimodal mass spectrometry imaging workflow to classify liver cell types and metabolic zones at single-cell resolution in human tissue.

bioRxiv · Sep 26, 2022 · PreprintCell Biology

A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

S. J. Resnick, S. Iketani, S. J. Hong, A. Zask, H. Liu, S. Kim, S. Melore, M. S. Nair, Y. Huang, N. E. S. Tay, T. Rovis, H. W. Yang, B. R. Stockwell, D. D. Ho, A. Chavez

This paper introduces a cell-based assay to identify coronavirus 3CL protease inhibitors without live virus, demonstrating its effectiveness through compound screening and structure-activity profiling.

bioRxiv · Aug 29, 2020 · PreprintMicrobiology

Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

S. Iketani, F. Forouhar, H. Liu, S. J. Hong, F.-Y. Lin, M. S. Nair, A. Zask, Y. Huang, L. Xing, B. R. Stockwell, A. Chavez, D. D. Ho

The paper identifies three structurally diverse compounds as inhibitors of the SARS-CoV-2 3CL protease and provides structural insights for inhibitor design.

bioRxiv · Aug 3, 2020Microbiology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology