F. Vandenesch

Proteomic assay for rapid characterization of Staphylococcus aureus antimicrobial resistance directly from blood cultures

This paper presents a rapid proteomic method using LC-MS/MS to detect and quantify key antimicrobial resistance proteins in Staphylococcus aureus directly from blood cultures with high sensitivity and specificity.

Complex regulation of gamma-hemolysin expression impacts S. aureus virulence

This study shows that variations in gamma-hemolysin CB expression in S. aureus isolates correlate with mortality in a rabbit pneumonia model, driven by promoter activity, mRNA stability, and a single SNP affecting translation.

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.

Staphylococcus aureus virulence factor expression matters: input from targeted proteomics shows Panton-Valentine leucocidin impact on mortality

A targeted proteomic method analyzed 44 Staphylococcus aureus virulence factors in 136 pneumonia strains, showing PVL's dose-dependent impact on mortality.

YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro

This study shows YAP enhances cell-autonomous immune responses against intracellular Staphylococcus aureus by promoting autophagy and inflammation.

All Staphylococcus aureus bacteraemia strains have the potential to cause infective endocarditis: results of GWAS and experimental animal studies

This study shows that all Staphylococcus aureus bacteraemia strains can cause infective endocarditis, as no genetic differences were found between IE and non-IE strains using GWAS and experimental models.

Trophic cooperation promotes bacterial survival of Staphylococcus aureus and Pseudomonas aeruginosa

This study shows that acetoin, produced by S. aureus, benefits both S. aureus and P. aeruginosa by providing a carbon source and reducing acetoin toxicity, indicating trophic cooperation in CF lungs.

Potential role of Mercury pollutants in the success of Methicillin-Resistant Staphylococcus aureus USA300 in Latin America

The paper investigates how mercury pollution may contribute to the dominance of a USA300 variant in South America by enhancing its fitness under mercury exposure.

NorK, a novel norfloxacin efflux pump in Staphylococcus aureus

The paper identifies NorK, a new norfloxacin efflux pump in Staphylococcus aureus that contributes to resistance and is expressed independently of MgrA regulation.

Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells

Metapopulation ecology links antibiotic resistance, consumption and patient transfers in a network of hospital wards

The paper uses metapopulation ecology to analyze how antibiotic use and patient transfers affect antibiotic resistance in hospital wards, finding strong links between antibiotic consumption and resistance variants.

A dual sRNA in Staphylococcus aureus induces a metabolic switch responding to glucose consumption

The paper identifies RsaI, a CcpA-dependent sRNA in S. aureus that mediates a metabolic switch in response to glucose availability.

Demographic fluctuation of community-acquired antibiotic-resistant Staphylococcus aureus lineages: potential role of flimsy antibiotic exposure

The paper investigates how low-level antibiotic exposure influences the expansion of two CA-MRSA lineages by reversing the fitness cost of antibiotic resistance.