Author

F.-C. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell signaling & trafficking· 8 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

P. Bassereau· 8 shared J. Manzi· 3 shared P. Lappalainen· 3 shared A. Bertin· 2 shared A. Di Cicco· 2 shared E. Lemichez· 2 shared H. Bousquet· 2 shared J. Pernier· 2 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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8 shared papersBiophysics

P. Bassereau

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Author profile →

11 papers

Recent·Most cited

STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik.

B. Rambaud, M. Joseph, F.-C. Tsai, C. V. De Jamblinne, E. Del Guidice, R. Sabelli, P. Bassereau, D. R. Hipfner, S. Carreno

This study identifies STRIPAK's role in promoting cytoneme biogenesis through Slik's membrane-sculpting function, which drives cell proliferation in Drosophila.

bioRxiv · Mar 4, 2024 · PreprintCell Biology

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

C. Morel, E. Lemerle, F.-C. Tsai, T. Obadia, N. Srivastava, M. Marechal, A. Salles, M. Albert, C. Stefani, Y. Benito, F. Vandenesch, C. Lamaze, S. Vassilopoulos, M. Piel, P. Bassereau, , E. Lemichez

This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.

bioRxiv · Sep 27, 2022Biophysics

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

L. Picas, F. Comunale, C. Andre-Arpin, H. Bousquet, F.-C. Tsai, F. Rico, P. Maiuri, J. Pernier, S. Bodin, A.-S. Nicot, J. Laporte, P. Bassereau, B. Goud, C. Gauthier-Rouviere, S. Miserey

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

bioRxiv · Mar 21, 2022Cell Biology

Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions

F.-C. Tsai, J. M. Henderson, Z. Jarin, E. Kremneva, Y. Senju, J. Pernier, O. Mikhajlov, J. Manzi, K. Kogan, C. Le Clainche, G. A. Voth, P. Lappalainen, P. Bassereau

The paper investigates how IRSp53 clustering regulates filopodia initiation by recruiting VASP to form actin-based membrane protrusions.

bioRxiv · Mar 4, 2022Biophysics

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

A. K. Cada, M. Remec Pavlin, J. P. Castillo, A. B. Tong, K. P. Larsen, X. Ren, A. L. Yokom, F.-C. Tsai, J. Shiah, P. Bassereau, C. J. Bustamante, J. H. Hurley

This study shows that CHMP1B and IST1 can sever membranes through a friction-driven mechanism, requiring constriction and extensional force, but not VPS4 or spastin.

bioRxiv · Feb 3, 2022 · PreprintBiophysics

PI4P and BLOC-1 remodel endosomal membranes into tubules

R. A. Jani, A. Di Cicco, T. Keren-Kaplan, S. Vale-Costa, D. Hamaoui, I. Hurbain, F.-C. Tsai, M. Dimarco, A.-S. Mace, Y. Zhu, M. J. Amorim, P. Bassereau, J. S. Bonifacino, A. Subtil, M. S. Marks, , C. Delevoye

This study shows how PI4P and BLOC-1 coordinate to form and stabilize endosomal tubules, essential for membrane remodeling and pathogen trafficking.

bioRxiv · Oct 21, 2021Cell Biology

Cytoplasmic forces functionally reorganize nuclear condensates in oocytes

A. Al Jord, G. Letort, S. Chanet, F.-C. Tsai, C. Antoniewski, A. Eichmuller, C. Da Silva, J.-R. HUYNH, N. Gov, R. Voituriez, M.-E. Terret, M.-H. Verlhac

This study shows that cytoplasmic forces reorganize nuclear condensates in oocytes, affecting mRNA processing and meiotic divisions.

bioRxiv · Mar 15, 2021 · PreprintCell Biology

Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration

L.-Y. Yu, T.-J. Tseng, H.-C. Lin, T.-X. Lu, C.-J. Tsai, Y.-C. Lin, C.-L. Hsu, F.-C. Tsai

The paper identifies an integrated STK40-YAP-MAPK system that regulates cell migration and introduces synthetic dysmobility as a strategy to disrupt migration by blocking collaborative pathways.

bioRxiv · Feb 15, 2021Cell Biology

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53.

K. Inamdar, F.-C. Tsai, A. dePoret, R. Dibsy, J. Manzi, P. Merida, R. Muller, P. Lappalainen, P. Roingeard, J. Mak, P. Bassereau, C. Favard, D. MURIAUX

This study shows that IRSp53 assists HIV-1 in forming membrane curvature necessary for complete particle assembly.

bioRxiv · Feb 10, 2021Biophysics

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

F. Iv, C. Silva Martins, G. Castro-Linares, C. Taveneau, P. Barbier, P. Verdier-Pinard, L. Camoin, S. Audebert, F.-C. Tsai, L. Ramond, A. Llewellyn, M. Belhabib, K. Nakazawa, A. Di Cicco, R. Vincentelli, , M. Mavrakis

This study isolates recombinant human septin octamers with distinct SEPT9 isoforms and shows they form filament assemblies and bind actin filaments.

bioRxiv · Jan 21, 2021Cell Biology

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

F.-C. Tsai, A. Bertin, H. Bousquet, J. Manzi, Y. Senju, M.-C. Tsai, L. Picas, S. Miserey-Lenkei, P. Lappalainen, E. Lemichez, E. Coudrier, P. Bassereau

This study investigates how ezrin enrichment on curved membranes depends on its conformation or interaction with curvature-sensitive partners, showing that specific conformations and binding to I-BAR-domain proteins enable targeting to curved membranes.

bioRxiv · Apr 12, 2018Biophysics