Jonathan Higham

Local CpG density affects the trajectory of age-associated epigenetic changes

The paper shows that local CpG density influences age-related DNA methylation changes in humans by analyzing longitudinal methylation data and SNP data from 600 individuals.

De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

The paper shows de novo DNA methyltransferases in colorectal cancer target H3K36me3-marked CpG islands, similar to normal tissues, rather than sequence-specific CpG islands.

An epigenetic predictor of death captures multi-modal measures of brain health

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

Age-related clonal haemopoiesis is associated with increased epigenetic age

The paper shows that age-related clonal haemopoiesis is linked to accelerated epigenetic age.