Author

G. Alsaleh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. K. Simon· 3 shared H. Zhang· 2 shared M. Borsa· 2 shared A. Meyer· 1 shared C. Behrends· 1 shared C. Edwards· 1 shared C. Green· 1 shared D. J. Puleston· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

A. K. Simon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

D. Zhou, M. Borsa, D. J. Puleston, S. Zellner, J. Capera, S. Sanderson, L. Jostins, C. Behrends, G. Alsaleh, A. K. Simon

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

bioRxiv · Dec 8, 2021 · PreprintImmunology

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

F. C. Richter, M. Friedrich, N. Kampschulte, M. Pohin, G. Alsaleh, I. Guschina, S. K. Wideman, E. Johnson, M. Borsa, K. Piletic, P. Hahn, H. S. Schipper, C. Edwards, R. Zechner, N. H. Schebb, , A. K. Simon

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

bioRxiv · Oct 25, 2021Immunology

Autophagy in T cells from aged donors is maintained by spermidine, and correlates with function and vaccine responses

G. Alsaleh, I. Panse, L. Swadling, H. Zhang, A. Meyer, J. Lord, E. Barnes, P. Klenerman, C. Green, K. Simon

This study shows that spermidine maintains autophagy in aged human T cells, improving vaccine responses by enhancing IFN-gamma secretion and T cell function.

bioRxiv · Jun 1, 2020Physiology

Translational control of TFEB and autophagy via eIF5A rejuvenates B cell immunity

H. Zhang, G. Alsaleh, J. Feltham, Y. Sun, T. Riffelmacher, P. Charles, L. Frau, Z. Yu, S. Mohammed, S. Balabanov, J. Mellor, A. K. Simon

This study identifies a mechanism by which spermidine regulates autophagy through eIF5A-mediated TFEB translation, improving B cell immunity in aging.

bioRxiv · Dec 12, 2018 · PreprintCell Biology