Author

X. Hong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 3 Cell Biology· 3 Biochemistry· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 15 Organism:human· 9 Research Focus:cell type annotation· 7 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell-cell communication· 3

Frequent Co-Authors

H. Wang· 3 shared Y. Wang· 3 shared D. Liu· 2 shared G. Wang· 2 shared H. Huang· 2 shared H. Zhang· 2 shared J. Tian· 2 shared K. Li· 2 shared

Activity by Year

2017-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

H. Wang

Mutual co-authors in cluster

Author profile →

17 papers

Recent·Most cited

Yes1-mediated Cul9 phosphorylation promotes the metabolic reprogramming in gastric cancer

Y. Wu, H. Zhang, S. Zhang, M. Wang, H. Wang, H. Huang, X. Hong, Z. Zhang, Y. Li

This study identifies Yes1-mediated Cul9 phosphorylation as a driver of metabolic reprogramming in gastric cancer, revealing a feedback loop with therapeutic implications.

bioRxiv · Oct 18, 2023 · PreprintCancer Biology

A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency

V. Pham, L. S. Finoti, M. M. Cassidy, J. A. Maguire, A. L. Gagne, E. A. Waxman, D. L. French, K. King, P. Wongkittichotee, X. Hong, L. Schlotawa, B. L. Davidson, R. C. Ahrens-Nicklas

This paper creates an iPSC model of Multiple Sulfatase Deficiency, showing that neurons become more vulnerable to SUMF1 loss during differentiation.

bioRxiv · Oct 2, 2023Cell Biology

Exomap1 mouse: a transgenic model for in vivo studies of exosome biology

F. K. Fordjour, S. Abuelreich, X. Hong, E. Chatterjee, V. Lallai, M. Ng, A. Saftics, F. Deng, N. Carnel-Amar, H. Wakimoto, K. Shimizu, T. Anh Phu, N. K. Vu, P. C. Geiger, R. L. Raffai, , S. Gould

The exomap1 mouse model expresses HsCD81mNG to study exosome biology in vivo, showing cell type-specific exosome contributions and confirming CD81 as an exosome-specific marker.

bioRxiv · May 29, 2023 · PreprintCell Biology

Leafhopper transmits soybean stay-green associated virus to legume plants

J. Yin, Z. Hu, S. Xu, X. Hong, Y. Qiu, X. Cheng, L. Wang, W. Sheng, H. Zhi, K. Li, K. Xu

This study identifies leafhoppers as vectors for SoSGV, a virus associated with soybean stay-green syndrome, and shows they can transmit the virus to legume plants.

bioRxiv · Jan 5, 2023 · PreprintMicrobiology

IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

X. Hong, H. Ren, T. Wang, L. Wei, S. Meng, W. Song, Y. Chen, H. Li, Q. Zhao, Z. Jiang, D. Liu

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

bioRxiv · Jan 4, 2023 · PreprintImmunology

A photopolymerizable hydrogel enhances intramyocardial vascular cell delivery and promotes post-myocardial infarction healing by polarizing pro-regenerative neutrophils

X. Hong, A. C. Luo, I. Doulamis, N. Oh, G.-B. Im, P. J. del Nido, J. M. M. Martin, R.-Z. Lin

This study develops a GelMA hydrogel to enhance vascular cell retention in myocardial infarction, improving cardiac healing through neutrophil polarization.

bioRxiv · Jun 30, 2022 · PreprintBioengineering

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

Y. Xiao, W. Jin, K. Qian, K. Wu, G. Wang, W. Jiang, R. Cao, L. Ju, Y. Zhao, H. Zheng, T. Liu, L. Chang, Z. Xu, T. Wang, J. Luo, , X. Wang

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

bioRxiv · Oct 30, 2021 · PreprintCancer Biology

Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

Y. Cong, C. Liu, H. Wang, M. Jin, W. Han, S. Wang, Y. Wang, F. Wang, C. Su, X. Hong, Q. Zhao

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

bioRxiv · Feb 24, 2021 · PreprintBiochemistry

Mutation of IDR1 enhances drought tolerance by reducing ROS production and activating ROS scavenging in rice

X. Zu, Y. Lu, Q. Wang, Y. La, F. Tan, J. Niu, H. Xia, X. Hong, Y. Wu, S. Zhou, K. Li, H. Chen, S. Qiang, Q. Rui, H. Wang, H. La

bioRxiv · Aug 24, 2020 · PreprintPlant Biology

In Vivo Transcriptomic Profiling using Cell Encapsulation Identifies Effector Pathways of Systemic Aging

O. Mashinchian, X. Hong, J. Michaud, E. Migliavacca, G. Lefebvre, C. Boss, F. De Franceschi, E. Le Moal, J. Collerette-Tremblay, J. Isern, S. Metairon, F. Raymond, P. Descombes, N. Bouche, P. Munoz-Canoves, , C. F. Bentzinger

This study uses cell encapsulation to profile systemic aging in vivo and identifies Myc and E2F activation, senescence, and suppressed myogenic differentiation as key pathways.

bioRxiv · Mar 9, 2020Bioengineering

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

K. Wang, R.-Z. Lin, X. Hong, A. Ng, C.-N. Lee, J. Neumeyer, G. Wang, X. Wang, M. Ma, W. Pu, G. Church, J. Melero-Martin

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

bioRxiv · Mar 2, 2020Cell Biology

JMJD6 Cleaves MePCE to Release P-TEFb

G. Zhang, S. Lee, H. Liu, R. Hill, X. Hong, X. Liu, F. Crawford, Q. Zhang, M. Kingsley, Z. Chen, A. Lengeling, K. Bernet, P. Marrack, J. Kappler, K. Hansen, , C.-Y. Li

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

bioRxiv · Aug 5, 2019 · PreprintBiochemistry

TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis

P. Zhang, X. Li, Q. He, L. Zhang, K. Song, X. Yang, Q. He, Y. Wang, X. Hong, J. Ma, N. Liu

This study identifies TRIM21-SERPINB5 as a mechanism promoting radioresistance in nasopharyngeal carcinoma by repressing TP53 through GMPS degradation.

bioRxiv · Apr 16, 2019Cancer Biology

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

H. Zhang, R. Zhang, X. Yang, K.-J. Gu, W. Chen, Y. Chang, Q. Xu, Q. Liu, Y. Qin, X. Hong, P.-P. Yin, I. Seim, H.-Y. Lin, W.-H. Li, J. Tian, , X. Liu

The paper resolves the sex-determination system in Ginkgo biloba, identifying XY chromosomes and five potential sex-determination genes originating ~14 million years ago.

bioRxiv · Jan 11, 2019 · PreprintEvolutionary Biology

Garcinia cambogia extract removes calcium oxalate kidney stones in both genetic and non-genetic Drosophila models of nephrolithiasis

Q. Fan, X. Feng, X. Hong, S. Gong, J. Tian, F. Hou, F. Zhang

This study shows Garcinia cambogia extract removes calcium oxalate kidney stones in Drosophila models, suggesting a potential therapeutic strategy for nephrolithiasis.

bioRxiv · Nov 27, 2018 · PreprintPharmacology & Toxicology

Injectable osteogenic microtissues containing mesenchymal stromal cells conformally fill and repair critical-size defects

R. T. Annamalai, X. Hong, N. Schott, G. Tiruchinapally, B. Levi, J. Stegemann

This study develops injectable osteogenic microtissues with MSCs to repair bone defects, showing that pre-differentiated MSCs promote complete bone bridging.

bioRxiv · Nov 9, 2018Bioengineering

Targeting posttranslational modifications of RioK1 inhibits the progression of colorectal and gastric cancers

X. Hong, H. Huang, Z. Ding, X. Feng, Y. Zhu, H. Zhuo, J. Hou, W. Cai, X. Hong, H. Song, Z. Zhang

This study identifies posttranslational modifications of RioK1 that regulate its stability and oncogenic activity in colorectal and gastric cancers.

bioRxiv · Aug 1, 2017Cancer Biology