Author

R. Sauerwein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. W. Kooij· 2 shared A. S. P. YANG· 1 shared A. VARDAKIS· 1 shared A.E. Hauser· 1 shared B. Campo· 1 shared C. A. Beuckens-Schortinghuis· 1 shared C. Drakeley· 1 shared C. Fischli· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPharmacology & Toxicology

T. W. Kooij

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites

N. J. KATRIS, Y. YAMARYO-BOTTE, J. JANOUSKOVEC, S. SHUNMUGAM, C.-S. ARNOLD, A. S. P. YANG, A. VARDAKIS, R. STEWART, R. SAUERWEIN, G. McFADDEN, C. J. TONKIN, M.-F. CESBRON-DELAUW, C. Y. BOTTE

The paper investigates the rapid lipid second messenger dynamics in Toxoplasma tachyzoites, showing how cGMP signaling regulates membrane lipid turnover and coordinates invasion and egress.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum

J. Schalkwijk, E. L. Allman, P. A. Jansen, L. E. de Vries, S. Jackowski, P. N. Botman, C. A. Beuckens-Schortinghuis, K. M. Koolen, J. M. Bolscher, M. W. Vos, K. Miller, S. Reeves, H. Pett, G. Trevitt, S. Wittlin, , K. J. Dechering

Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum.

bioRxiv · Feb 12, 2018Pharmacology & Toxicology

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

L. Meerstein-Kessel, R. van der Lee, W. Stone, K. Lanke, D. A. Baker, P. Alano, F. Silvestrini, C. J. Janse, S. M. Khan, M. van de Vegte-Bolmer, W. Graumans, R. Siebelink-Stoter, T. W. Kooij, M. Marti, C. Drakeley, , M. A. Huynen

The paper integrates omics data to identify gametocyte-specific genes and transcripts in malaria parasites, finding novel biomarkers and validating their expression in natural infections.

bioRxiv · Jan 11, 2018Microbiology

Non-competitive resource exploitation within-mosquito shapes evolution of malaria virulence

G. Costa, M. Gildenhard, M. Eldering, R.L. Lindquist, A.E. Hauser, R. Sauerwein, C. Goosmann, V. Brinkmann, E.A. Levashina

This study shows that mosquito lipid trafficking affects Plasmodium virulence by shaping sporozoite development and metabolic activity, revealing a vector-driven mechanism in malaria virulence evolution.

bioRxiv · Oct 27, 2017 · PreprintEvolutionary Biology